172 nations and a number of candidate vaccines engaged in COVID-19 vaccine Global Access Facility

  • Nine CEPI-supported candidate vaccines are a part of the COVAX initiative, with an extra 9 candidates below analysis, and procurement conversations on-going with further producers not at present receiving analysis and growth (R&D) funding by way of COVAX – giving COVAX the most important and most numerous COVID-19 vaccine portfolio on the earth
  • 80 doubtlessly self-financing nations have submitted non-binding expressions of curiosity to the Gavi-coordinated COVAX Facility, becoming a member of 92 low- and middle-income economies which are eligible to be supported by the COVAX Advance Market Commitment (AMC)
  • Goal of bringing the pandemic below management by way of equitable entry to COVID-19 vaccines wants pressing, broadscale dedication and funding from nations

172 economies at the moment are engaged in discussions to doubtlessly take part in COVAX, a world initiative geared toward working with vaccine producers to supply nations worldwide equitable entry to secure and efficient vaccines,
as soon as they’re licensed and authorised. COVAX at present has the world’s largest and most numerous COVID-19 vaccine portfolio – together with 9 candidate vaccines, with an extra 9 below analysis and conversations underway with different >

COVAX, the vaccines pillar of the Access to COVID-19 Tools (ACT) Accelerator, is co-led by the Coalition for Epidemic Preparedness Innovations (CEPI), Gavi, the Vaccine Alliance, and the World Health Organization (WHO) – working in partnership with
developed and creating nation vaccine producers. It is the one international initiative that’s working with governments and producers to make sure COVID-19 vaccines can be found worldwide to each higher-income and lower->

In order to have the ability to safe sufficient doses of vaccines to guard essentially the most weak populations, similar to well being staff and the aged, the subsequent step for the partnership is to verify potential self-financing contributors’ intent to take part
by 31 August and to show these into binding commitments to hitch the COVID-19 Vaccine Global Access Facility (COVAX Facility) by 18th of September, with first upfront funds to comply with thereafter, and no later than 9th of October 2020.

“Equal access to a COVID-19 vaccine is the key to beating the virus and paving the way for recovery from the pandemic,” mentioned Stefan Löfven, Prime Minister of Sweden. “This can’t be a race with a number of winners, and the COVAX Facility
is a vital a part of the answer – ensuring all nations can profit from entry to the world’s largest portfolio of candidates and truthful and equitable distribution of vaccine doses.”

The COVAX Facility is a Gavi-coordinated pooled procurement mechanism for brand new COVID-19 vaccines, by way of which COVAX will guarantee truthful and equitable entry to vaccines for every taking part financial system, utilizing an allocation framework at present being formulated
by WHO. The COVAX Facility will do that by pooling shopping for energy from taking part economies and offering quantity ensures throughout a variety of promising vaccine candidates, permitting these vaccine producers whose experience is important to giant
scale manufacturing of the brand new vaccines, to make early, at-risk investments in manufacturing capability – offering taking part nations and economies with the most effective probability at speedy entry to doses of a profitable COVID-19 vaccine.

The success of COVAX hinges not solely on nations signing as much as the COVAX Facility, but in addition filling key funding gaps for each COVAX R&D work and a mechanism to help participation of lower-income economies within the COVAX Facility.

“COVID-19 is an unprecedented global health challenge that can only be met with unprecedented cooperation between governments, researchers, manufacturers and multilateral partners,” mentioned Dr Tedros Adhanom Ghebreyesus, Director-General of WHO.
“By pooling resources and acting in solidarity through the ACT Accelerator and the COVAX Facility, we can ensure that once a vaccine is available for COVID-19, it’s available equitably to all countries.”

CEPI is main COVAX vaccine analysis and growth work, which goals to develop three secure and efficient vaccines which might be made accessible to nations taking part within the COVAX Facility. Nine candidate vaccines are at present being supported by
CEPI; seven of that are at present in medical trials. Governments, vaccine producers (along with their very own R&D), organizations and people have dedicated US$ 1.four billion in direction of vaccine R&D up to now, however a further US$1 billion is urgently wanted
to proceed to maneuver the portfolio ahead.

An additional 9 candidates vaccines which enhance the present CEPI portfolio are at present being evaluated for inclusion in COVAX.  Furthermore, COVAX will take into account procuring vaccines that complement the portfolio from any producer on the earth;
conversations are already underway with quite a few further producers not receiving R&D help from CEPI to acquire their vaccines if they’re profitable. Maximizing the portfolio of vaccines will increase the likelihood of success as particular person
vaccines traditionally have a excessive failure charge.

“In the scramble for a vaccine, nations can act alone – creating a number of winners, and lots of losers – or they will come collectively to take part in COVAX, an initiative which is constructed on enlightened self-interest but in addition fairness, leaving no nation
behind,” mentioned Richard Hatchett, CEO of CEPI. “Only by taking a world view can we shield these most in danger world wide from the horrible results of this illness. COVAX can ship the vaccines that might finish the pandemic, but it surely
wants nations to step ahead each to hitch the COVAX Facility, and likewise to handle the intense funding shortfalls, together with for R&D. The choices which are taken now about COVID-19 vaccines have the facility to alter our future. We should be brave
and impressive in striving for a multilateral answer.”

A collaboration between Serum Institute of India (SII), Gavi and the Bill & Melinda Gates Foundation announced earlier this month will guarantee as much as 100 million doses of AstraZeneca or Novavax’s candidate vaccines, if profitable, shall be accessible to low- and middle-income economies by way of the COVAX Facility at simply US$ three per dose. The association additionally offers an choice
to safe further doses if COVAX sees a necessity for it. Separate agreements between Gavi, CEPI and AstraZeneca, introduced in June, assure an extra 300 million doses of their candidate vaccine, if profitable, for the COVAX Facility.

In addition, in June Gavi launched the COVAX Advance Market Commitment (AMC), a financing instrument geared toward supporting the participation of
92 lower and middle income economies within the COVAX Facility. The COVAX AMC has raised greater than US$ 600 million towards an preliminary goal of securing US$ 2 billion seed funding from sovereign donors
in addition to philanthropy and the personal sector, wanted by the top of 2020. Funding the COVAX AMC shall be crucial to making sure skill to pay is just not a barrier to accessing COVID-19 vaccines, a state of affairs which would go away the
majority of the world unprotected, with the pandemic and its impression persevering with unabated.  

80 higher-income economies, which might finance the vaccines from their very own public finance budgets, have up to now submitted Expressions of Interest forward of the 31 of August deadline for affirmation of intent to take part. They will associate with 92 low-
and middle-income nations that shall be supported by the AMC if it meets its funding targets. To gether, this group of 172 nations represents greater than 70% of the world’s inhabitants. Among the group are representatives from each continent
and greater than half of the world’s G20 economies.


“The momentum we are witnessing behind this unprecedented global effort means there could be light at the end of the tunnel: A vaccine is our best route to ending the acute phase of the pandemic and the COVAX effort is the best way to get there,”
mentioned Dr Seth Berkley, CEO of Gavi, the Vaccine Alliance. “For higher-income nations it represents a win-win: not solely will you be assured entry to the world’s largest portfolio of vaccines, additionally, you will be negotiating as a part of
a world consortium, bringing down costs and guaranteeing really international entry. Signing as much as the COVAX Facility offers every nation its greatest probability at defending essentially the most weak members of their populations – which in flip offers the world its
greatest probability at mitigating the toll this pandemic has taken on people, communities and the worldwide financial system. To make this end-to-end imaginative and prescient a actuality, we’d like nations to make end-to-end commitments: funding R&D, signing as much as the Facility,
and supporting the COVAX AMC.”

The COVAX Facility is coordinated by Gavi, the Vaccine Alliance, and kinds a key a part of COVAX – the vaccines pillar of the ACT Accelerator, a ground-breaking international collaboration involving vaccine producers to speed up the event, manufacturing,
and equitable entry to COVID-19 assessments, therapies, and vaccines. The total purpose of COVAX is to speed up the event and manufacture of COVID-19 vaccines, and to ensure truthful and equitable entry for each nation on the earth. It will obtain
this by sharing the dangers related to vaccine growth, and the place crucial investing in manufacturing upfront so vaccines might be deployed at scale as quickly as they’re confirmed to be secure and efficient, and pooling procurement and buying
energy to realize ample volumes to finish the acute section of the pandemic by 2021.

The objective of COVAX is by the top of 2021 to ship two billion doses of secure, efficient vaccines which have handed regulatory approval and/or WHO prequalification. These vaccines shall be provided equally to all taking part nations, proportional to their
populations, initially prioritising healthcare staff then increasing to cowl weak teams, such because the aged and people with pre-existing circumstances. Further doses will then be made accessible primarily based on nation want, vulnerability and COVID-19
menace. The COVAX Facility will even preserve a buffer of doses for emergency and humanitarian use, together with coping with extreme outbreaks earlier than they spiral uncontrolled. 



Notes to editors

The full listing of CEPI-supported candidate vaccines is as follows:

  • Inovio, United States of America (Phase I/II)
  • Moderna, United States of America (Phase III)
  • CureVac, Germany (Phase I)
  • Institut Pasteur/Merck/Themis, France/ United States of America /Austria (Preclinical)
  • AstraZeneca/University of Oxford, United Kingdom of Great Britain and Northern Ireland (Phase III)
  • University of Hong Kong, China (Preclinical)
  • Novavax, United States of America (Phase I/II)
  • Clover Biopharmaceuticals, China (Phase I)
  • University of Queensland/CSL, Australia (Phase I)

The 9 candidate vaccines which are at present being evaluated for inclusion within the COVAX Facility embrace two from China, two from the United States of America, one from the People’s Republic of Korea, one from the United Kingdom of Great Britain and Northern Ireland and one international, multi-manufacture partnership. Two of those are in Phase I trials, two are tech transfers and the rest are on the discovery stage.

The 80 nations which have submitted expressions of curiosity to the Gavi-coordinated COVAX Facility embrace 43 which have agreed to be publicly named: Andorra, Argentina, Armenia, Botswana, Brazil, Canada, Chile, Colombia, Croatia, Czech Republic, Dominican Republic, Estonia, Finland, Greece, Iceland, Iraq, Ireland, Israel, Japan, Jordan, Kuwait, Lebanon, Luxembourg, Mauritius, Mexico, Monaco, Montenegro, New Zealand, North Macedonia, Norway, Palau, Portugal, Qatar, the People’s Republic of Korea, San Marino, Saudi Arabia, Seychelles, Singapore, South Africa, Switzerland, United Arab Emirates, United Kingdom of Great Britain and Northern Ireland and Venezuela.

In July the Gavi Board agreed on the 92 economies that shall be supported the COVAX Advance Market Commitment (AMC). The full listing is as follows:

  • Low revenue: Afghanistan, Benin, Burkina Faso, Burundi, Central African Republic, Chad, the Democratic Republic of the Congo, Eritrea, Ethiopia, Gambia, Guinea, Guinea-Bissau, Haiti, Democratic People’s Republic of Korea, Liberia, Madagascar, Malawi, Mali, Mozambique, Nepal, Niger, Rwanda, Sierra Leone, Somalia, South Sudan, Syrian Arab Republic, Tajikistan, Togo, Uganda, United Republic of Tanzania  and Yemen.
  • Lower-middle revenue: Angola, Algeria, Bangladesh, Bhutan, Bolivia, Cabo Verde, Cambodia, Cameroon, Comoros, Congo, Côte d’Ivoire, Djibouti, Egypt, El Salvador, Eswatini, Ghana, Honduras, India, Indonesia, Kenya, Kiribati, Kyrgyztan, Lao People’s Democratic Republic, Lesotho, Mauritania, Micronesia, Moldova, Mongolia, Morocco, Myanmar, Nicaragua, Nigeria, Pakistan, Papua New Guinea, Philippines, São Tomé and Principe, Senegal, Solomon Islands, Sri Lanka, Sudan, Timor-Leste, Tunisia, Ukraine, Uzbekistan, Vanuatu, Vietnam, West Bank and Gaza, Zambia and Zimbabwe
  • Additional IDA eligible: Dominica, Fiji, Grenada, Guyana, Kosovo, Maldives, Marshall Islands, Samoa, St. Lucia, St. Vincent and the Grenadines, Tonga and Tuvalu.

About Gavi, the Vaccine Alliance

Gavi, the Vaccine Alliance is a public-private partnership that helps vaccinate half the world’s youngsters towards a number of the world’s deadliest ailments. Since its inception in 2000, Gavi has helped to immunise an entire technology – over 760 million youngsters – and prevented greater than 13 million deaths, serving to to halve youngster mortality in 73 creating nations. Gavi additionally performs a key function in bettering international well being safety by supporting well being methods in addition to funding international stockpiles for Ebola, cholera, meningitis and yellow fever vaccines.  After twenty years of progress, Gavi is now targeted on defending the subsequent technology and reaching the unvaccinated youngsters nonetheless being left behind, using revolutionary finance and the most recent know-how – from drones to biometrics – to save lots of thousands and thousands extra lives, stop outbreaks earlier than they will unfold and assist nations on the street to self-sufficiency. Learn extra at www.gavi.org and join with us on Facebook and Twitter.

The Vaccine Alliance brings collectively creating nation and donor governments, the World Health Organization, UNICEF, the World Bank, the vaccine trade, technical businesses, civil society, the Bill & Melinda Gates Foundation and different personal sector companions. View the complete listing of donor governments and different main organizations that fund Gavi’s work here.

About CEPI

CEPI is an revolutionary partnership between public, personal, philanthropic, and civil organisations, launched at Davos in 2017, to develop vaccines to cease future epidemics. CEPI has moved with nice urgency and in coordination with WHO in response to the emergence of COVID-19. CEPI has initiated 9 partnerships to develop vaccines towards the novel coronavirus. The programmes are leveraging speedy response platforms already supported by CEPI in addition to new partnerships.

Before the emergence of COVID-19, CEPI’s precedence ailments included Ebola virus, Lassa virus, Middle East Respiratory Syndrome coronavirus, Nipah virus, Rift Valley Fever and Chikungunya virus. CEPI additionally invested in platform applied sciences that can be utilized for speedy vaccine and immunoprophylactic growth towards unknown pathogens (Disease X).  

About WHO

The World Health Organization offers international management in public well being throughout the United Nations system. Founded in 1948, WHO works with 194 Member States, throughout six areas and from greater than 150 places of work, to advertise well being, hold the world secure and serve the weak. Our objective for 2019-2023 is to make sure that a billion extra folks have common well being protection, to guard a billion extra folks from well being emergencies, and supply an extra billion folks with higher well being and wellbeing.

For updates on COVID-19 and public well being recommendation to guard your self from coronavirus, go to www.who.int and comply with WHO on TwitterFacebookInstagramLinkedInTikTokPinterestSnapchatYouTube